Mutations in Polymerase Genes Enhanced the Virulence of 2009 Pandemic H1N1 Influenza Virus in Mice
Identifieur interne : 000A39 ( Main/Exploration ); précédent : 000A38; suivant : 000A40Mutations in Polymerase Genes Enhanced the Virulence of 2009 Pandemic H1N1 Influenza Virus in Mice
Auteurs : Wenfei Zhu ; Yun Zhu ; Kun Qin ; Zaijiang Yu ; Rongbao Gao ; Huiyan Yu ; Jianfang Zhou ; Yuelong ShuSource :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Influenza A virus can infect a wide variety of animal species with illness ranging from mild to severe, and is a continual cause for concern. Genetic mutations that occur either naturally or during viral adaptation in a poorly susceptible host are key mechanisms underlying the evolution and virulence of influenza A virus. Here, the variants containing PA-A36T or PB2-H357N observed in the mouse-adapted descendants of 2009 pandemic H1N1 virus (pH1N1), A/Sichuan/1/2009 (SC), were characterized. Both mutations enhanced polymerase activity in mammalian cells. These effects were confirmed using recombinant SC virus containing polymerase genes with wild type (WT) or mutant PA or PB2. The PA-A36T mutant showed enhanced growth property compared to the WT in both human A549 cells and porcine PK15 cells
Url:
DOI: 10.1371/journal.pone.0033383
PubMed: 22438920
PubMed Central: 3305307
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mutations in Polymerase Genes Enhanced the Virulence of 2009 Pandemic H1N1 Influenza Virus in Mice</title>
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<front><div type="abstract" xml:lang="en"><p>Influenza A virus can infect a wide variety of animal species with illness ranging from mild to severe, and is a continual cause for concern. Genetic mutations that occur either naturally or during viral adaptation in a poorly susceptible host are key mechanisms underlying the evolution and virulence of influenza A virus. Here, the variants containing PA-A36T or PB2-H357N observed in the mouse-adapted descendants of 2009 pandemic H1N1 virus (pH1N1), A/Sichuan/1/2009 (SC), were characterized. Both mutations enhanced polymerase activity in mammalian cells. These effects were confirmed using recombinant SC virus containing polymerase genes with wild type (WT) or mutant PA or PB2. The PA-A36T mutant showed enhanced growth property compared to the WT in both human A549 cells and porcine PK15 cells <italic>in vitro</italic>
, without significant effect on viral propagation in murine LA-4 cells and pathogenicity in mice; however, it did enhance the lung virus titer. PB2-H357N variant demonstrated growth ability comparable to the WT in A549 cells, but replicated well in PK15, LA-4 cells and in mice with an enhanced pathogenic phenotype. Despite such mutations are rare in nature, they could be observed in avian H5 and H7 subtype viruses which were currently recognized to pose potential threat to human. Our findings indicated that pH1N1 may adapt well in mammals when acquiring these mutations. Therefore, future molecular epidemiological surveillance should include scrutiny of both markers because of their potential impact on pathogenesis.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pappas, C" uniqKey="Pappas C">C Pappas</name>
</author>
<author><name sortKey="Aguilar, Pv" uniqKey="Aguilar P">PV Aguilar</name>
</author>
<author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name>
</author>
<author><name sortKey="Sol Rzano, A" uniqKey="Sol Rzano A">A Solórzano</name>
</author>
<author><name sortKey="Zeng, H" uniqKey="Zeng H">H Zeng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hale, Bg" uniqKey="Hale B">BG Hale</name>
</author>
<author><name sortKey="Randall, Re" uniqKey="Randall R">RE Randall</name>
</author>
<author><name sortKey="Ortin, J" uniqKey="Ortin J">J Ortín</name>
</author>
<author><name sortKey="Jackson, D" uniqKey="Jackson D">D Jackson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Conenello, Gm" uniqKey="Conenello G">GM Conenello</name>
</author>
<author><name sortKey="Zamarin, D" uniqKey="Zamarin D">D Zamarin</name>
</author>
<author><name sortKey="Perrone, La" uniqKey="Perrone L">LA Perrone</name>
</author>
<author><name sortKey="Tumpey, T" uniqKey="Tumpey T">T Tumpey</name>
</author>
<author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scholtissek, C" uniqKey="Scholtissek C">C Scholtissek</name>
</author>
<author><name sortKey="Rohd, W" uniqKey="Rohd W">W Rohd</name>
</author>
<author><name sortKey="Von Hoyningen, V" uniqKey="Von Hoyningen V">V Von Hoyningen</name>
</author>
<author><name sortKey="Rott, R" uniqKey="Rott R">R Rott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Basler, Cf" uniqKey="Basler C">CF Basler</name>
</author>
<author><name sortKey="Aguilar, Pv" uniqKey="Aguilar P">PV Aguilar</name>
</author>
<author><name sortKey="Zeng, H" uniqKey="Zeng H">H Zeng</name>
</author>
<author><name sortKey="Sol Rzano, A" uniqKey="Sol Rzano A">A Solórzano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
<author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Labadie, K" uniqKey="Labadie K">K Labadie</name>
</author>
<author><name sortKey="Dos Santos Afonso, E" uniqKey="Dos Santos Afonso E">E Dos Santos Afonso</name>
</author>
<author><name sortKey="Rameix Welti, Ma" uniqKey="Rameix Welti M">MA Rameix-Welti</name>
</author>
<author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name>
</author>
<author><name sortKey="Naffakh, N" uniqKey="Naffakh N">N Naffakh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naffakh, N" uniqKey="Naffakh N">N Naffakh</name>
</author>
<author><name sortKey="Massin, P" uniqKey="Massin P">P Massin</name>
</author>
<author><name sortKey="Escriou, N" uniqKey="Escriou N">N Escriou</name>
</author>
<author><name sortKey="Crescenzo Chaigne, B" uniqKey="Crescenzo Chaigne B">B Crescenzo-Chaigne</name>
</author>
<author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name>
</author>
<author><name sortKey="Beyer, We" uniqKey="Beyer W">WE Beyer</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subbarao, Ek" uniqKey="Subbarao E">EK Subbarao</name>
</author>
<author><name sortKey="London, W" uniqKey="London W">W London</name>
</author>
<author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name>
</author>
<author><name sortKey="Gao, P" uniqKey="Gao P">P Gao</name>
</author>
<author><name sortKey="Halfmann, P" uniqKey="Halfmann P">P Halfmann</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gabriel, G" uniqKey="Gabriel G">G Gabriel</name>
</author>
<author><name sortKey="Dauber, B" uniqKey="Dauber B">B Dauber</name>
</author>
<author><name sortKey="Wolff, T" uniqKey="Wolff T">T Wolff</name>
</author>
<author><name sortKey="Planz, O" uniqKey="Planz O">O Planz</name>
</author>
<author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mehle, A" uniqKey="Mehle A">A Mehle</name>
</author>
<author><name sortKey="Doudna, Ja" uniqKey="Doudna J">JA Doudna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gabriel, G" uniqKey="Gabriel G">G Gabriel</name>
</author>
<author><name sortKey="Abram, M" uniqKey="Abram M">M Abram</name>
</author>
<author><name sortKey="Keiner, B" uniqKey="Keiner B">B Keiner</name>
</author>
<author><name sortKey="Wagner, R" uniqKey="Wagner R">R Wagner</name>
</author>
<author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fornek, Jl" uniqKey="Fornek J">JL Fornek</name>
</author>
<author><name sortKey="Gillim Ross, L" uniqKey="Gillim Ross L">L Gillim-Ross</name>
</author>
<author><name sortKey="Santos, C" uniqKey="Santos C">C Santos</name>
</author>
<author><name sortKey="Carter, V" uniqKey="Carter V">V Carter</name>
</author>
<author><name sortKey="Ward, Jm" uniqKey="Ward J">JM Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steel, J" uniqKey="Steel J">J Steel</name>
</author>
<author><name sortKey="Lowen, Ac" uniqKey="Lowen A">AC Lowen</name>
</author>
<author><name sortKey="Mubareka, S" uniqKey="Mubareka S">S Mubareka</name>
</author>
<author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bussey, Ka" uniqKey="Bussey K">KA Bussey</name>
</author>
<author><name sortKey="Bousse, Tl" uniqKey="Bousse T">TL Bousse</name>
</author>
<author><name sortKey="Desmet, Ea" uniqKey="Desmet E">EA Desmet</name>
</author>
<author><name sortKey="Kim, B" uniqKey="Kim B">B Kim</name>
</author>
<author><name sortKey="Takimoto, T" uniqKey="Takimoto T">T Takimoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Puthavathana, P" uniqKey="Puthavathana P">P Puthavathana</name>
</author>
<author><name sortKey="Auewarakul, P" uniqKey="Auewarakul P">P Auewarakul</name>
</author>
<author><name sortKey="Charoenying, Pc" uniqKey="Charoenying P">PC Charoenying</name>
</author>
<author><name sortKey="Sangsiriwut, K" uniqKey="Sangsiriwut K">K Sangsiriwut</name>
</author>
<author><name sortKey="Pooruk, P" uniqKey="Pooruk P">P Pooruk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hulse Post, Dj" uniqKey="Hulse Post D">DJ Hulse-Post</name>
</author>
<author><name sortKey="Franks, J" uniqKey="Franks J">J Franks</name>
</author>
<author><name sortKey="Boyd, K" uniqKey="Boyd K">K Boyd</name>
</author>
<author><name sortKey="Salomon, R" uniqKey="Salomon R">R Salomon</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Jiao, P" uniqKey="Jiao P">P Jiao</name>
</author>
<author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name>
</author>
<author><name sortKey="Tian, G" uniqKey="Tian G">G Tian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name>
</author>
<author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Sakoda, Y" uniqKey="Sakoda Y">Y Sakoda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Libster, R" uniqKey="Libster R">R Libster</name>
</author>
<author><name sortKey="Bugna, J" uniqKey="Bugna J">J Bugna</name>
</author>
<author><name sortKey="Coviello, S" uniqKey="Coviello S">S Coviello</name>
</author>
<author><name sortKey="Hijano, Dr" uniqKey="Hijano D">DR Hijano</name>
</author>
<author><name sortKey="Dunaiewsky, M" uniqKey="Dunaiewsky M">M Dunaiewsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maines, Tr" uniqKey="Maines T">TR Maines</name>
</author>
<author><name sortKey="Jayaraman, A" uniqKey="Jayaraman A">A Jayaraman</name>
</author>
<author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name>
</author>
<author><name sortKey="Wadford, Da" uniqKey="Wadford D">DA Wadford</name>
</author>
<author><name sortKey="Pappas, C" uniqKey="Pappas C">C Pappas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name>
</author>
<author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name>
</author>
<author><name sortKey="Schrauwen, Ej" uniqKey="Schrauwen E">EJ Schrauwen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bautista, E" uniqKey="Bautista E">E Bautista</name>
</author>
<author><name sortKey="Chotpitayasunondh, T" uniqKey="Chotpitayasunondh T">T Chotpitayasunondh</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Harper, Sa" uniqKey="Harper S">SA Harper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, Ms" uniqKey="Song M">MS Song</name>
</author>
<author><name sortKey="Pascua, Pn" uniqKey="Pascua P">PN Pascua</name>
</author>
<author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
<author><name sortKey="Baek, Yh" uniqKey="Baek Y">YH Baek</name>
</author>
<author><name sortKey="Park, Kj" uniqKey="Park K">KJ Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Halpin, R" uniqKey="Halpin R">R Halpin</name>
</author>
<author><name sortKey="Hine, E" uniqKey="Hine E">E Hine</name>
</author>
<author><name sortKey="Spiro, Dj" uniqKey="Spiro D">DJ Spiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name>
</author>
<author><name sortKey="Schmolke, M" uniqKey="Schmolke M">M Schmolke</name>
</author>
<author><name sortKey="Varga, Zt" uniqKey="Varga Z">ZT Varga</name>
</author>
<author><name sortKey="Manicassamy, B" uniqKey="Manicassamy B">B Manicassamy</name>
</author>
<author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name>
</author>
<author><name sortKey="Chutinimitkul, S" uniqKey="Chutinimitkul S">S Chutinimitkul</name>
</author>
<author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name>
</author>
<author><name sortKey="Sorrell, Em" uniqKey="Sorrell E">EM Sorrell</name>
</author>
<author><name sortKey="Cai, Y" uniqKey="Cai Y">Y Cai</name>
</author>
<author><name sortKey="Shao, H" uniqKey="Shao H">H Shao</name>
</author>
<author><name sortKey="Xu, K" uniqKey="Xu K">K Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ilyushina, Na" uniqKey="Ilyushina N">NA Ilyushina</name>
</author>
<author><name sortKey="Khalenkov, Am" uniqKey="Khalenkov A">AM Khalenkov</name>
</author>
<author><name sortKey="Seiler, Jp" uniqKey="Seiler J">JP Seiler</name>
</author>
<author><name sortKey="Forrest, Hl" uniqKey="Forrest H">HL Forrest</name>
</author>
<author><name sortKey="Bovin, Nv" uniqKey="Bovin N">NV Bovin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chutinimitkul, S" uniqKey="Chutinimitkul S">S Chutinimitkul</name>
</author>
<author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name>
</author>
<author><name sortKey="Steel, J" uniqKey="Steel J">J Steel</name>
</author>
<author><name sortKey="Lowen, Ac" uniqKey="Lowen A">AC Lowen</name>
</author>
<author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Childs, Ra" uniqKey="Childs R">RA Childs</name>
</author>
<author><name sortKey="Matrosovich, T" uniqKey="Matrosovich T">T Matrosovich</name>
</author>
<author><name sortKey="Wharton, S" uniqKey="Wharton S">S Wharton</name>
</author>
<author><name sortKey="Palma, As" uniqKey="Palma A">AS Palma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name>
</author>
<author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name>
</author>
<author><name sortKey="Staker, Bl" uniqKey="Staker B">BL Staker</name>
</author>
<author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name>
</author>
<author><name sortKey="Imai, M" uniqKey="Imai M">M Imai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seyer, R" uniqKey="Seyer R">R Seyer</name>
</author>
<author><name sortKey="Hrincius, Er" uniqKey="Hrincius E">ER Hrincius</name>
</author>
<author><name sortKey="Ritzel, D" uniqKey="Ritzel D">D Ritzel</name>
</author>
<author><name sortKey="Abt, M" uniqKey="Abt M">M Abt</name>
</author>
<author><name sortKey="Mellmann, A" uniqKey="Mellmann A">A Mellmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sakabe, S" uniqKey="Sakabe S">S Sakabe</name>
</author>
<author><name sortKey="Ozawa, M" uniqKey="Ozawa M">M Ozawa</name>
</author>
<author><name sortKey="Takano, R" uniqKey="Takano R">R Takano</name>
</author>
<author><name sortKey="Iwastuki Horimoto, K" uniqKey="Iwastuki Horimoto K">K Iwastuki-Horimoto</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name>
</author>
<author><name sortKey="Liu, Lq" uniqKey="Liu L">LQ Liu</name>
</author>
<author><name sortKey="Zhou, Jf" uniqKey="Zhou J">JF Zhou</name>
</author>
<author><name sortKey="Zhu, Wf" uniqKey="Zhu W">WF Zhu</name>
</author>
<author><name sortKey="Qin, K" uniqKey="Qin K">K Qin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fodor, E" uniqKey="Fodor E">E Fodor</name>
</author>
<author><name sortKey="Devenish, L" uniqKey="Devenish L">L Devenish</name>
</author>
<author><name sortKey="Engelhardt, Og" uniqKey="Engelhardt O">OG Engelhardt</name>
</author>
<author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name>
</author>
<author><name sortKey="Brownlee, Gg" uniqKey="Brownlee G">GG Brownlee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reed, Lj" uniqKey="Reed L">LJ Reed</name>
</author>
<author><name sortKey="Muench, H" uniqKey="Muench H">H Muench</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, Wf" uniqKey="Zhu W">WF Zhu</name>
</author>
<author><name sortKey="Zhou, Jf" uniqKey="Zhou J">JF Zhou</name>
</author>
<author><name sortKey="Qin, K" uniqKey="Qin K">K Qin</name>
</author>
<author><name sortKey="Du, N" uniqKey="Du N">N Du</name>
</author>
<author><name sortKey="Liu, Lq" uniqKey="Liu L">LQ Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name>
</author>
<author><name sortKey="Hatta, Y" uniqKey="Hatta Y">Y Hatta</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bussey, Ka" uniqKey="Bussey K">KA Bussey</name>
</author>
<author><name sortKey="Desmet, Ea" uniqKey="Desmet E">EA Desmet</name>
</author>
<author><name sortKey="Mattiacio, Jl" uniqKey="Mattiacio J">JL Mattiacio</name>
</author>
<author><name sortKey="Hamilton, A" uniqKey="Hamilton A">A Hamilton</name>
</author>
<author><name sortKey="Bradel Tretheway, B" uniqKey="Bradel Tretheway B">B Bradel-Tretheway</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name>
</author>
<author><name sortKey="Lourens, Rm" uniqKey="Lourens R">RM Lourens</name>
</author>
<author><name sortKey="Wang, R" uniqKey="Wang R">R Wang</name>
</author>
<author><name sortKey="Jin, G" uniqKey="Jin G">G Jin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name>
</author>
<author><name sortKey="Chang, G" uniqKey="Chang G">G Chang</name>
</author>
<author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ilyushina, Na" uniqKey="Ilyushina N">NA Ilyushina</name>
</author>
<author><name sortKey="Ducatez, Mf" uniqKey="Ducatez M">MF Ducatez</name>
</author>
<author><name sortKey="Rehg, Je" uniqKey="Rehg J">JE Rehg</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nieto, A" uniqKey="Nieto A">A Nieto</name>
</author>
<author><name sortKey="De La Luna, S" uniqKey="De La Luna S">S de la Luna</name>
</author>
<author><name sortKey="Barcena, J" uniqKey="Barcena J">J Bárcena</name>
</author>
<author><name sortKey="Portela, A" uniqKey="Portela A">A Portela</name>
</author>
<author><name sortKey="Ortin, J" uniqKey="Ortin J">J Ortín</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yuan, P" uniqKey="Yuan P">P Yuan</name>
</author>
<author><name sortKey="Bartlam, M" uniqKey="Bartlam M">M Bartlam</name>
</author>
<author><name sortKey="Lou, Z" uniqKey="Lou Z">Z Lou</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawaguchi, A" uniqKey="Kawaguchi A">A Kawaguchi</name>
</author>
<author><name sortKey="Naito, T" uniqKey="Naito T">T Naito</name>
</author>
<author><name sortKey="Nagata, K" uniqKey="Nagata K">K Nagata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fodor, E" uniqKey="Fodor E">E Fodor</name>
</author>
<author><name sortKey="Crow, M" uniqKey="Crow M">M Crow</name>
</author>
<author><name sortKey="Mingay, Lj" uniqKey="Mingay L">LJ Mingay</name>
</author>
<author><name sortKey="Deng, T" uniqKey="Deng T">T Deng</name>
</author>
<author><name sortKey="Sharps, J" uniqKey="Sharps J">J Sharps</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boivin, S" uniqKey="Boivin S">S Boivin</name>
</author>
<author><name sortKey="Cusack, S" uniqKey="Cusack S">S Cusack</name>
</author>
<author><name sortKey="Ruigrok, Rw" uniqKey="Ruigrok R">RW Ruigrok</name>
</author>
<author><name sortKey="Hart, Dj" uniqKey="Hart D">DJ Hart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, J" uniqKey="Song J">J Song</name>
</author>
<author><name sortKey="Feng, H" uniqKey="Feng H">H Feng</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Zhao, D" uniqKey="Zhao D">D Zhao</name>
</author>
<author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Qin, K" uniqKey="Qin K">K Qin</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Pu, J" uniqKey="Pu J">J Pu</name>
</author>
<author><name sortKey="Tang, Q" uniqKey="Tang Q">Q Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guilligay, D" uniqKey="Guilligay D">D Guilligay</name>
</author>
<author><name sortKey="Tarendeau, F" uniqKey="Tarendeau F">F Tarendeau</name>
</author>
<author><name sortKey="Resa Infante, P" uniqKey="Resa Infante P">P Resa-Infante</name>
</author>
<author><name sortKey="Hart, Dj" uniqKey="Hart D">DJ Hart</name>
</author>
<author><name sortKey="Cusack, S" uniqKey="Cusack S">S Cusack</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name>
</author>
<author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name>
</author>
<author><name sortKey="Pybus, Og" uniqKey="Pybus O">OG Pybus</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name>
</author>
<author><name sortKey="Bhatt, S" uniqKey="Bhatt S">S Bhatt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dundon, Wg" uniqKey="Dundon W">WG Dundon</name>
</author>
<author><name sortKey="De Benedictis, P" uniqKey="De Benedictis P">P De Benedictis</name>
</author>
<author><name sortKey="Viale, E" uniqKey="Viale E">E Viale</name>
</author>
<author><name sortKey="Capua, I" uniqKey="Capua I">I Capua</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sponseller, Ba" uniqKey="Sponseller B">BA Sponseller</name>
</author>
<author><name sortKey="Strait, E" uniqKey="Strait E">E Strait</name>
</author>
<author><name sortKey="Jergens, A" uniqKey="Jergens A">A Jergens</name>
</author>
<author><name sortKey="Trujillo, J" uniqKey="Trujillo J">J Trujillo</name>
</author>
<author><name sortKey="Harmon, K" uniqKey="Harmon K">K Harmon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lohr, Cv" uniqKey="Lohr C">CV Löhr</name>
</author>
<author><name sortKey="Debess, Ee" uniqKey="Debess E">EE DeBess</name>
</author>
<author><name sortKey="Baker, Rj" uniqKey="Baker R">RJ Baker</name>
</author>
<author><name sortKey="Hiett, Sl" uniqKey="Hiett S">SL Hiett</name>
</author>
<author><name sortKey="Hoffman, Ka" uniqKey="Hoffman K">KA Hoffman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weingartl, Hm" uniqKey="Weingartl H">HM Weingartl</name>
</author>
<author><name sortKey="Berhane, Y" uniqKey="Berhane Y">Y Berhane</name>
</author>
<author><name sortKey="Hisanaga, T" uniqKey="Hisanaga T">T Hisanaga</name>
</author>
<author><name sortKey="Neufeld, J" uniqKey="Neufeld J">J Neufeld</name>
</author>
<author><name sortKey="Kehler, H" uniqKey="Kehler H">H Kehler</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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<tree><noCountry><name sortKey="Gao, Rongbao" sort="Gao, Rongbao" uniqKey="Gao R" first="Rongbao" last="Gao">Rongbao Gao</name>
<name sortKey="Qin, Kun" sort="Qin, Kun" uniqKey="Qin K" first="Kun" last="Qin">Kun Qin</name>
<name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name>
<name sortKey="Yu, Huiyan" sort="Yu, Huiyan" uniqKey="Yu H" first="Huiyan" last="Yu">Huiyan Yu</name>
<name sortKey="Yu, Zaijiang" sort="Yu, Zaijiang" uniqKey="Yu Z" first="Zaijiang" last="Yu">Zaijiang Yu</name>
<name sortKey="Zhou, Jianfang" sort="Zhou, Jianfang" uniqKey="Zhou J" first="Jianfang" last="Zhou">Jianfang Zhou</name>
<name sortKey="Zhu, Wenfei" sort="Zhu, Wenfei" uniqKey="Zhu W" first="Wenfei" last="Zhu">Wenfei Zhu</name>
<name sortKey="Zhu, Yun" sort="Zhu, Yun" uniqKey="Zhu Y" first="Yun" last="Zhu">Yun Zhu</name>
</noCountry>
</tree>
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